LONG NON-CODING RNA MALAT1 REGULATES OXALIPLATIN-RESISTANCE VIA MIR-324-3P/ADAM17 AXIS IN COLORECTAL CANCER CELLS

Long non-coding RNA MALAT1 regulates oxaliplatin-resistance via miR-324-3p/ADAM17 axis in colorectal cancer cells

Abstract Background Colorectal cancer (CRC) is one of the most general malignant tumors.Accumulating evidence implied that long non-coding RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) participated in the tumorigenesis of CRC.However, the effect of MALAT1 in drug-resistance needed to be further illustrated.Methods Levels of MA

read more


Growth, exclusion and vulnerability: evaluation of the socio-spatial transformation of post-apartheid Pretoria-Tshwane (South Africa)

Apartheid left South African city regions with two major challenges: social integration at a city level and spatial integration at a regional level.The task to finds solutions to these problems was left to municipalities, the lowest level of the three trier government system introduced after 1994.This article critically evaluates the success of the

read more

Delayed contrast enhancement imaging of a murine model for ischemia reperfusion with carbon nanotube micro-CT.

We aim to demonstrate the application of free-breathing prospectively gated carbon nanotube (CNT) micro-CT by evaluating a myocardial infarction model with a delayed contrast enhancement technique.Evaluation of murine cardiac models using micro-CT imaging has historically been limited by extreme imaging requirements.Newly-developed CNT-based x-ray

read more